Cells nonproductively transformed by Abelson murine leukemia virus express a high molecular weight polyprotein containing structural and nonstructural components.
نویسندگان
چکیده
منابع مشابه
Cells nonproductively transformed by Abelson murine leukemia virus express a high molecular weight polyprotein containing structural and nonstructural components.
Cell clones nonproductively transformed by the replication-defective Abelson strain of murine leukemia virus (AbLV) were analyzed for type C viral antigen expression by competition immunoassay. AbLV-transformed mink non-producer lines were found to express a 110,000- to 130,000-molecular weight polyprotein containing murine leukemia virus gag proteins p15 and p12 covalently linked to nonstructu...
متن کاملVirus production by Abelson murine leukemia virus-transformed lymphoid cells.
Cell lines obtained by in vitro transformation of bone marrow with Abelson murine leukemia virus (A-MuLV) can be divided into three classes: producers, releasing reverse transcriptase-containing particles and infectious virus; nonproducers, releasing no viral particles; and defective producers, the most common phenotype, releasing particulate reverse transcriptase in the absence of infectious v...
متن کاملAbelson Murine Leukemia Virus-transformed
Transformation of murine adult bone marrow cells by Abelson Murine Leukemia Virus (A-MuLV)' can result in the generation of permanent cell lines (Abelson lines) representing early stages of B lymphocyte differentiation (1) . Because it is difficult to obtain large numbers of B cell precursors capable of Ig gene recombination from normal cell populations, Abelson cell lines provide an accessible...
متن کاملMurine leukemia virus (T-8)-transformed cells: identification of a precursor polyprotein containing gag gene-coded proteins (p15 and p12) and a nonstructural component.
Mink cells nonproductively transformed by the T-8 strain of mink cell focus-inducing virus express two type C viral amino terminal gag gene-coded structural proteins, p15 and p12, in the form of a 90,000 to 110,000 molecular weight polyprotein that lacks detectable immunological reactivity with other known type C virus-coded translational products. The observation concurs with the previous demo...
متن کاملRelationship of surface membranes of lymphoid cells transformed by Abelson murine leukemia virus to tumor rejection.
The Abelson murine leukemia virus (A-MuLV)-transformed lymphoid cell line L1-2 is exceptional since it is rejected follow ing transplantation into syngeneic C57L mice. Furthermore, the serum from recovered mice (Abelson tumor serum) has been used as a source of antibodies to abl antigens present in the M, 120,000 A-MuLV-encoded gag-abl fusion protein (p120). In addition to p120, this antiserum ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1978
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.75.8.3974